Synthesis of 4-methylpropiophenone from toluene by Friedel-Crafts reaction (1kg+ scale)

[CryoThio]

Are there any other Lewis acids that can be used to synthesize 4mmc from toluene?

Aluminum chloride is hard to obtain for me.

 

[HectorFromTroy]

Yes, for example Iron chloride (FeCl3) and zinc chloride (ZnCl3) but the reaction will happen at a slower rate compared to using aluminium chloride.

 

[CryoThio]

Yes, for example Iron chloride (FeCl3) and zinc chloride (ZnCl3) but the reaction will happen at a slower rate compared to using aluminium chloride.

HectorFromTroyThe zinc and iron chlorides are anhydrous?

Which of those two give the faster reaction?

 

[HectorFromTroy]

The zinc and iron chlorides are anhydrous?

Which of those two give the faster reaction?

CryoThioYes they are both anhydrous and from the two iron (iii) chloride (FeCl3) would work the best

 

[HectorFromTroy]

ZnCl2* not ZnCl3

 

[Germanium]

How to synthesize 3-methylpropiophenone?

 

[oneimone]

yo yo. for small synthesis the ratio of substrates are the same 3:1:1,5 or something changes?

 

[The-Hive]

Divided it by 10